- STANDARDISED TO 98% BERBERINE HCL
- NATURAL SUPPLEMENT
- BERBERINE INFLUENCES GLUCOSE METABOLISM
- UP TO 90 PORTIONS PER PACKAGE
- BERBERINE PROTECTS THE LIVER
- CONVENIENT CAPSULE FORM
ALLNUTRITION BERBERINE HCL is a food supplement containing barberry bark extract (Berberis aristata) in tablets standardised to 98% berberine HCL. The product contains 90 servings. This alkaloid, which is present in various parts of plants such as bark, roots and leaves, is often used for its properties.
WHY SUPPLEMENTING WITH BERBERINE IS WORTHWHILE?
Berberine supplementation may be considered by adults who wish to support carbohydrate metabolism and liver health due to berberine's potential properties, which are still being extensively researched.
INFLUENCE ON GLUCOSE METABOLISM
According to some sources, berberine improves insulin sensitivity. This may be due to its effect on the expression of so-called lipogenic genes [1]. Furthermore, many authors claim that berberine can act similarly to metformin – directly influencing AMPK activity [2-3], which is an enzyme whose activation inhibits glucose and fat synthesis. Additionally, chronic AMPK activation resembles the effect of intense physical exercise [4].
LIVER PROTECTION
In one study, berberine was shown to protect the liver, among other things due to its antioxidant properties and its effect on the activity of detoxification enzymes [5,6].
Source:
[1] Yun S. Lee, Woo S. Kim, Kang H. Kim, Myung J. Yoon, Hye J. Cho,Yun Shen, Ji-Ming Ye, Chul H. Lee, Won K. Oh, Chul T. Kim, Cordula Hohnen-Behrens, Alison Gosby, Edward W. Kraegen, David E. James, Jae B. Kim: Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States. Diabetes, vol. 55, August, 2006, 2256 – 2264.
[2] Nabrdalik K., Cichocka E., Gumprecht J.: Metformina a kinaza białkowa aktywowana przez AMP (AMPK) i procesy energetyczne w cukrzycy typu 2. Diabetologia Kliniczna 2013, tom 2, nr 4. ISSN 2084–4441.
[3] You-Jin Ch., Kang-Yo L., Seung-Hwan J., Hyung Sik K., Gayong S., Mi-Gyeong K., Yu-Kyoung O., Seon-Hee O., Dae Won J., Byung-Hoon L.: Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicology and Applied Pharmacology. Vol. 316, 1 February 2017, p. 74-82.
[4] Nabrdalik K., Cichocka E., Gumprecht J.: Metformina a kinaza białkowa aktywowana przez AMP (AMPK) i procesy energetyczne w cukrzycy typu 2. Diabetologia Kliniczna 2013, tom 2, nr 4. ISSN 2084–4441.
[5] Zhu X., Guo X., Mao G., Gao Z., Wang H., He Q., Li D.: Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of Sirtuin 1. Phytother Res. 2013 Mar;27(3):417-21
[6] Imenshahidi M., Hosseinzadeh H.: Berberis Vulgaris and Berberine: An Update Review. Phytother Res. 2016 Nov;30(11):1745-1764.
*Due to the restrictions imposed by the regulations governing food supplements, we regret that we are unable to provide full details of the properties of certain ingredients, formulas, vitamins and minerals.