ALLNUTRITION BERBERINE is a dietary supplement containing barberry root extract (Berberis aristata) standardised to 2% berberine, which belongs to the group of alkaloids. Berberine has a positive effect on liver health and also influences glucose metabolism.
A FEW WORDS ABOUT BERBERINE...
Berberine is a natural alkaloid. It has a unique spectrum of properties and occurs naturally in various plants, especially those of the Berberis genus.
Berberine has been used in traditional medicine due to its many properties.
LIVER HEALTH
Research shows that berberine has liver-protective properties. This is due, among other things, to its antioxidant effect and its influence on the activity of enzymes responsible for detoxification in the body [1,2].
INFLUENCE ON GLUCOSE METABOLISM
An increasing number of studies suggest that berberine may be a natural way to improve insulin sensitivity. This may be due to its effect on the expression of so-called lipogenic genes [3]. In addition, according to many authors, berberine may act similarly to metformin – directly affecting AMPK activity [4, 5], i.e. the enzyme whose activation inhibits glucose and fat synthesis. In addition, chronic AMPK activation resembles the effect of intense physical exercise [6].
Source:
[1] Zhu X., Guo X., Mao G., Gao Z., Wang H., He Q., Li D.: Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of Sirtuin 1. Phytother Res. 2013 Mar;27(3):417-21
[2] Imenshahidi M., Hosseinzadeh H.: Berberis Vulgaris and Berberine: An Update Review. Phytother Res. 2016 Nov;30(11):1745-1764.
[3] Yun S. Lee, Woo S. Kim, Kang H. Kim, Myung J. Yoon, Hye J. Cho,Yun Shen, Ji-Ming Ye, Chul H. Lee, Won K. Oh, Chul T. Kim, Cordula Hohnen-Behrens, Alison Gosby, Edward W. Kraegen, David E. James, Jae B. Kim: Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States. Diabetes, vol. 55, August, 2006, 2256 – 2264.
[4] Nabrdalik K., Cichocka E., Gumprecht J.: Metformina a kinaza białkowa aktywowana przez AMP (AMPK) i procesy energetyczne w cukrzycy typu 2. Diabetologia Kliniczna 2013, tom 2, nr 4. ISSN 2084–4441.
[5] You-Jin Ch., Kang-Yo L., Seung-Hwan J., Hyung Sik K., Gayong S., Mi-Gyeong K., Yu-Kyoung O., Seon-Hee O., Dae Won J., Byung-Hoon L.: Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicology and Applied Pharmacology. Vol. 316, 1 February 2017, p. 74-82.
[6] Nabrdalik K., Cichocka E., Gumprecht J.: Metformina a kinaza białkowa aktywowana przez AMP (AMPK) i procesy energetyczne w cukrzycy typu 2. Diabetologia Kliniczna 2013, tom 2, nr 4. ISSN 2084–4441.
*Due to restrictions under food supplement regulations, we regret that we are unable to provide full details of the properties of certain ingredients, formulas, vitamins and minerals.